114084-78-5 Ibandronic acid AKSci G724
 
 
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  G724    
Ibandronic acid
, 98%
 
(1-Hydroxy-3-(methyl(pentyl)amino)propane-1,1-diyl)diphosphonic acid




IDENTITY
CAS Number:114084-78-5
MDL Number:MFCD00868772
MF:C9H23NO7P2
MW:319.23
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White crystals
Melting Point:84°C
Density:1.5
Refractive Index:1.53
Long-Term Storage:Store long-term at 2-8°C
HAZARDOUS MATERIALS INFORMATION
Not hazardous material

REVIEW

 Ibandronic acid is a potent bisphosphonate drug used in the prevention and treatment of osteoporosis in post-menopausal women. It may also be used to treat hypercalcemia (elevated blood calcium levels). The action of ibandronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Nitrogen-containing bisphosphonates such as ibrandronate appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting farnesyl pyrophosphate (FPP) synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.

REFERENCES
[1]Jomaa, Hassan Medicaments containing bisphosphonic acids and their derivatives for prophylaxis and treatment of autoimmune diseases and allergies Ger. Offen. (1999), DE 19828450 A1 19991230.
[2] Bauss, Frieder; Pichler, Bernhard; Turley, Bisphosphonic acid for the treatment and prevention of osteoporosis Stephen PCT Int. Appl. (2003), WO 2003095029 A1 20031120.
[3] Burckhardt P.Ibandronate in oncology.Cancer. 1997 Oct 15;80(8 Suppl):1696-8.
[4] Dooley M, Balfour JA.Ibandronate.Drugs. 1999 Jan;57(1):101-8; discussion 109-10.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
H487Ibandronate sodium monohydrate
G724Ibandronic acid

Current as of September 22, 2020


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CATEGORIES

 APIs and Bioactives > Bisphosphonates


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