28860-95-9 S-(-)-Carbidopa AKSci F566
 
 
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  F566    
S-(-)-Carbidopa
, 98% (HPLC)
 
(S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid
S-(-)-alpha-Hydrazino-3,4-dihydroxy-2-methylbenzenepropanoic acid




IDENTITY
CAS Number:28860-95-9
MDL Number:MFCD00069231
MF:C10H14N2O4
MW:226.095
EINECS:249-271-9
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:203-208°C
Optical Rotation:-17.3° (c=0.3, MeOH)
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Aromatic-L-amino-acid decarboxylase inhibitor
Form:Free Base

REVIEW

 When mixed with levodopa, carbidopa inhibits the peripheral conversion of levodopa to dopamine and the decarboxylation of oxitriptan to serotonin by aromatic L-amino acid decarboxylase. This results in increased amount of levodopa and oxitriptan available for transport to the CNS. Carbidopa also inhibits the metabolism of levodopa in the GI tract, thus, increasing the bioavailability of levodopa.

REFERENCES
[1]Vickers S, Stuart EK, Bianchine JR, Hucker HB, Jaffe ME, Rhodes RE, Vandenheuvel WJ: Metabolism of carbidopa (1-(-)-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate), an aromatic amino acid decarboxylase inhibitor, in the rat, rhesus monkey, and man. Drug Metab Dispos. 1974 Jan-Feb;2(1):9-22.
[2] Vickers S, Stuart EK, Hucker HB: Further studies on the metabolism of carbidopa, (minus)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid monohydrate, in the human, Rhesus monkey, dog, and rat. J Med Chem. 1975 Feb;18(2):134-8.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
F566S-(-)-Carbidopa
H807Carbidopa monohydrate

Current as of October 6, 2022


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CATEGORIES

 APIs and Bioactives > DDC Inhibitors


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