5451-09-2 5-Aminolevulinic acid hydrochloride AKSci F147
 
 
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  F147    AKSci Bulk Reagent
5-Aminolevulinic acid hydrochloride, 98% (HPLC)
 
5-Amino-4-oxopentanoic acid hydrochloride
5-Aminolaevulinic acid hydrochloride
Levulan
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IDENTITY
CAS Number:5451-09-2
MDL Number:MFCD00012869
MF:C5H10ClNO3
MW:167.59
EINECS:226-679-5
BRN:3690651
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:154-162°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 34mg/mL; H2O: 34mg/mL; EtOH: 6mg/mL
Application(s):Intermediate in heme biosynthesis
Form:HCl salt

REVIEW
 5-Aminolevulinic acid hydrochloride is used as a photosensitizer for photodynamic detection and therapy for actinic keratosis. It is biosynthesized from succinyl-CoA and glycine and is the first compound in the porphyrin synthesis pathway. It elicits synthesis and accumulation of fluorescent porphyrins in epithelia and neoplastic tissues.

REFERENCES
[1]Herdeis, Claus; Dimmerling, Anna A three-step synthesis of epsilon-aminolevulinic acid Archiv der Pharmazie (Weinheim, Germany) (1984), 317(4), 304-6.
[2] Kawakami, Hiroshi; Ebata, Takashi; Matsushita, Hajime A new synthesis of 5-aminolevulinic acid Agricultural and Biological Chemistry (1991), 55(6), 1687-8.
[3] Matsumura, Yoshihiro; Takeshima, Yo-ichiro; Okita, Hideki A convenient method for introducing oxo group into the beta-position of cyclic amines and its application to synthesis of epsilon-aminolevulinic acid Bulletin of the Chemical Society of Japan (1994), 67(1), 304-6.
[4] Nokes B, Apel M, Jones C, Brown G, Lang JE.Aminolevulinic acid (ALA): photodynamic detection and potential therapeutic applications.J Surg Res. 2013 May;181(2):262-71.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
None

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

RELATED PRODUCTS
1451AA5-Amino-4-oxopentanoic acid
F1475-Aminolevulinic acid hydrochloride

Current as of September 22, 2023


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CATEGORIES
 APIs and Bioactives > Dermatology


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