4291-63-8 Cladribine AKSci E997
 
 
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  E997    AKSci Reference Standard
Cladribine
, 98% (HPLC)
 
2-Chloro-2'-deoxyadenosine




IDENTITY
CAS Number:4291-63-8
MDL Number:MFCD00153939
MF:C10H12ClN5O3
MW:285.69
EINECS:224-427-9
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Spectra:NMR, LCMS, FT-IR, HPLC, Polarimetry
Physical Form:White powder or crystalline powder
Melting Point:>220°C (dec.)
Optical Rotation:-18.8° (c=1,in DMF)
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO
Application(s):Adenosine deaminase inhibitor
Form:Free Base
Research Area:Multiple sclerosts

REVIEW

 Cladribine (trade names Litak and Movectro) is a purine nucleoside used to treat hairy cell leukemia (HCL, leukemic reticuloendotheliosis) and multiple sclerosis. It mimics the nucleoside adenosine and inhibiting the enzyme adenosine deaminase, which interferes with the cell''s ability to process DNA. It is easily destroyed by normal cells except for blood cells, with the result that it produces relatively few side effects and results in very little non-target cell loss.

REFERENCES
[1]Morris, Ashley K.; Kolesar, Jill M.; Kuhn, John G, Purine nucleoside analogs: fludarabine, pentostatin, and cladribine. Part 3: cladribine, Journal of Oncology Pharmacy Practice (1997), 3(2), 94-109.
[2] Juliusson, Gunnar; Liliemark, Jan; Mechanisms of action, pharmacokinetics, and routes of administration of 2-chlorodeoxyadenosine in hairy cell leukemia, Advances in Blood Disorders (2000), 5(Hairy Cell Leukemia), 163-170.
[3] Tallman, Martin S.; Hakimian, David; Hoffman, Mark A.; Rai, Kanti; Treatment of hairy cell leukemia with 2-chlorodeoxyadenosineAdvances in Blood Disorders (2000), 5(Hairy Cell Leukemia), 171-180.
[4] Goodman, Grant R.; Beutler, Ernest; Saven, Alan; Cladribine in the treatment of hairy-cell leukaemiaBest Practice & Research, Clinical Haematology (2003), 16(1), 101-116.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301+H311+H331; H315; H319; H335

Precautionary Statements
P261; P264; P270; P271; P280; P301+P310; P302+P352; P304+P340; P305+P351+P338; P312; P322; P330; P332+P313; P337+P313; P361; P403+P233; P405; P501


RELATED PRODUCTS
E997Cladribine
G787Clofarabine

Current as of September 21, 2021

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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For research use only. Not for diagnostic or therapeutic use. Not for human use. AK Scientific, Inc. does not sell to individuals. If you are a first-time customer, please email for review at least two official business documents issued by your local jurisdiction, state/province, or country.

WARNING: Attention California residents: This product can expose you to chemicals including Cladribine, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.


CATEGORIES

 APIs and Bioactives > Chemotherapeutics
 Nucleobases > Nucelosides
 Nucleobases > Nucelosides


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