42864-78-8 Bevantolol HCl AKSci E996
 
 
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  E996    AKSci Reference Standard
Bevantolol HCl
, 98% (HPLC)
 
Vantol




IDENTITY
CAS Number:42864-78-8
MDL Number:MFCD00941389
MF:C20H28ClNO4
MW:381.89
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Spectra:LCMS, HPLC
Physical Form:White to off-white crystals or powder
Melting Point:135-141°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Application(s):beta-1 Adrenoceptor antagonist
Form:HCl salt

REVIEW

 Bevantolol acts as both a beta blocker and a calcium channel blocker for the treatment of angina pectoris and hypertension. It possesses a relatively high degree of antagonistic selectivity for beta 1-adrenoceptors, thereby inhibiting normal epinephrine-mediated sympathetic actions such as increased heart rate. This has the effect of decreasing preload and blood pressure. It is devoid of intrinsic sympathomimetic activity and possesses only weak local anaesthetic properties. Interestingly, bevantolol has been shown to cause a lowering effect on peripheral vascular resistance.

REFERENCES
[1]Holmes, Ann; Meyer, Robert Frederick beta-Adrenergic blocking 1-(3,4-dimethoxyphenethylamino)-3-phenoxy-2-propanols Ger. Offen. (1973), DE 2259489 A1 19730705.
[2] Hoefle, Milton L.; Hastings, Stephen G.; Meyer, Robert F.; Corey, Ruth M.; Holmes, Ann; Stratton, Charlotte D. Cardioselective beta-adrenergic blocking agents. 1. 1-[(3,4-Dimethoxyphenethyl)amino]-3-aryloxy-2-propanols Journal of Medicinal Chemistry (1975), 18(2), 148-52.
[3] Hoekstra, Marvin S. 1-(3,4-Dimethoxyphenethylamino)-3-(substituted phenoxy)-2-propanols Eur. Pat. Appl. (1985), EP 165682 A1 19851227.
[4] Vaughan Williams EM: Bevantolol: a beta-1 adrenoceptor antagonist with unique additional actions. J Clin Pharmacol. 1987 Jul;27(7):450-60.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
C840Bevantolol
E996Bevantolol HCl

Current as of August 23, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Beta Blockers, Calcium Channel Blockers


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