42864-78-8 Bevantolol HCl AKSci E996
 
 
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  E996    
Bevantolol HCl, 98% (HPLC)
 
Vantol
IDENTITY
CAS Number:42864-78-8
MDL Number:MFCD00941389
MF:C20H28ClNO4
MW:381.89
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:135-141°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):beta-1 Adrenoceptor antagonist
Form:HCl salt

REVIEW
 Bevantolol acts as both a beta blocker and a calcium channel blocker for the treatment of angina pectoris and hypertension. It possesses a relatively high degree of antagonistic selectivity for beta 1-adrenoceptors, thereby inhibiting normal epinephrine-mediated sympathetic actions such as increased heart rate. This has the effect of decreasing preload and blood pressure. It is devoid of intrinsic sympathomimetic activity and possesses only weak local anaesthetic properties. Interestingly, bevantolol has been shown to cause a lowering effect on peripheral vascular resistance.

REFERENCES
[1]Holmes, Ann; Meyer, Robert Frederick beta-Adrenergic blocking 1-(3,4-dimethoxyphenethylamino)-3-phenoxy-2-propanols Ger. Offen. (1973), DE 2259489 A1 19730705.
[2] Hoefle, Milton L.; Hastings, Stephen G.; Meyer, Robert F.; Corey, Ruth M.; Holmes, Ann; Stratton, Charlotte D. Cardioselective beta-adrenergic blocking agents. 1. 1-[(3,4-Dimethoxyphenethyl)amino]-3-aryloxy-2-propanols Journal of Medicinal Chemistry (1975), 18(2), 148-52.
[3] Hoekstra, Marvin S. 1-(3,4-Dimethoxyphenethylamino)-3-(substituted phenoxy)-2-propanols Eur. Pat. Appl. (1985), EP 165682 A1 19851227.
[4] Vaughan Williams EM: Bevantolol: a beta-1 adrenoceptor antagonist with unique additional actions. J Clin Pharmacol. 1987 Jul;27(7):450-60.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

RELATED PRODUCTS
C840Bevantolol
E996Bevantolol HCl

Current as of September 22, 2024


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CATEGORIES
 APIs and Bioactives > Beta Blockers, Calcium Channel Blockers


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