1951-26-4 3-(4-Hydroxy-3,5-diiodo)-benzoyl-2-butyl benzofuran AKSci E326
 
 
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  E326    
3-(4-Hydroxy-3,5-diiodo)-benzoyl-2-butyl benzofuran
, 98% (HPLC)
 
(2-Butyl-1-benzofuran-3-yl)-(4-hydroxy-3,5-diiodophenyl)methanone
(2-Butylbenzofuran-3-yl)(4-hydroxy-3,5-diiodophenyl)ketone




IDENTITY
CAS Number:1951-26-4
MDL Number:MFCD02675787
MF:C19H16I2O3
MW:546.14
EINECS:217-773-7
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Spectra:NMR, HPLC
Physical Form:White to off-white powder
Melting Point:144-148°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:Soluble in methanol, and DMSO
Application(s):An analog of Amiodarone

REVIEW

 3-(4-Hydroxy-3,5-diiodo)-benzoyl-2-butyl benzofuran is an analog of the anti-arrhythmic compound Amiodarone HCl (Cat # F462). It results from O-dealkylation of the parent compound. Analogs of Amiodarone including this one were demonstrated to competitively inhibit 5'-T4 (thyroxine) deiodination.

REFERENCES
[1]Bigler, Laurent; European Journal of Medicinal Chemistry 2007, V42(6), P861-867
[2] Snead, Aaron N.; Bioorganic & Medicinal Chemistry Letters 2008, V18(22), P5920-5922
[3] Ha, H.R., et al. 2000. Eur. J. Clin. Pharmacol. 55: 807-814. PMID: 10805058

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
F462Amiodarone HCl
E3263-(4-Hydroxy-3,5-diiodo)-benzoyl-2-butyl benzofuran

Current as of August 22, 2019


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Arrhythmia


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