152459-95-5 Imatinib AKSci E118
 
 
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  E118    AKSci Reference Standard
Imatinib
, 99% (HPLC), powder
 
STI571
Glivec




IDENTITY
CAS Number:152459-95-5
MDL Number:MFCD05662257
MF:C29H31N7O
MW:493.6
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:208-213°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Protein Kinase Inhibitor; Tyrosine kinase enzymes specific inhibitor
Form:Free Base

REVIEW

 Imatinib works by blocking a central tyrosine kinase enzyme, in this case, BCR-ABL from phosphorylating subsequent proteins and initiating the signaling cascade necessary for cancer development. Because the BCR-ABL tyrosine kinase enzyme exists only in cancer cells and not in healthy cells, Imatinib is able to function as a targeted cancer therapy-only cancer cells are killed through the drug''s action. In this regard, Imatinib was one of the first cancer therapies to show the potential for such targeted action and of is often cited as a paradigm for research in cancer therapeutics.

REFERENCES
[1]Novartis Pharma AG. Gleevec® (imatinib mesylate) tablets prescribing information. East Hanover, NJ; 2006 Sep. Anon. Drugs of choice for cancer. Treat Guidel Med Lett. 2003; 1:41-52
[2] Goldman, J.M. & Melo, J.V. Chronic myeloid leukemia--advances in biology and new approaches to treatment. N Engl J Med 349, 1451-1464 (2003)
[3] Fausel, C. Targeted chronic myeloid leukemia therapy: Seeking a cure. Am J Health Syst Pharm 64, S9-15 (2007)
[4] Stegmeier, F., et al. (2010). Targeted Cancer Therapies in the Twenty-First Century: Lessons From Imatinib. Clin Pharmacol Ther 87(5): 543-552.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501


RELATED PRODUCTS
E118Imatinib
E412Imatinib methanesulfonate

Current as of September 29, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Protein Kinase Inhibitors


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