55268-75-2 Cefuroxime AKSci C679
 
 
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  C679    AKSci Reference Standard
Cefuroxime, 98% (HPLC)
 
Cephuroxime
Cefuroxim
Cefuroximo
more..
IDENTITY
CAS Number:55268-75-2
MDL Number:MFCD00864889
MF:C16H16N4O8S
MW:424.39
EINECS:259-560-1
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Spectra:LCMS, HPLC
Physical Form:White to light orange powder
Melting Point:178-182°C
Optical Rotation:+63.7° (c=1, 0.2M pH7 phosphate buffer)
Long-Term Storage:Store long-term at 2-8°C
HAZARDOUS MATERIALS INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Antibiotic

REVIEW
 Cefuroxime, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefuroxime interferes with an autolysin inhibitor.

REFERENCES
[1]Perry CM, Brogden RN: Cefuroxime axetil. A review of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy. Drugs. 1996 Jul;52(1):125-58.
[2] Kumar Singh, Santosh; Synthetic Communications 2003, V33(14), P2475-2482
[3] Robinson, Colin; DE 3432984 A1 1985
[4] Rajadurai, R.; Analytical Chemistry: An Indian Journal 2010, V9(2), P265-269

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

RELATED PRODUCTS
C679Cefuroxime
C718Cefuroxime sodium

Current as of February 27, 2021

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Antibacterials, Cephalosporins


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