55268-75-2 Cefuroxime AKSci C679
 
 
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  C679    
Cefuroxime
, 98% (HPLC)
 
Cephuroxime
Cefuroxim
Cefuroximo
more..




IDENTITY
CAS Number:55268-75-2
MDL Number:MFCD00864889
MF:C16H16N4O8S
MW:424.39
EINECS:259-560-1
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:178-182°C
Optical Rotation:+63.7° (c=1, 0.2M pH7 phosphate buffer)
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Antibiotic

REVIEW

 Cefuroxime, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefuroxime interferes with an autolysin inhibitor.

REFERENCES
[1]Perry CM, Brogden RN: Cefuroxime axetil. A review of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy. Drugs. 1996 Jul;52(1):125-58.
[2] Kumar Singh, Santosh; Synthetic Communications 2003, V33(14), P2475-2482
[3] Robinson, Colin; DE 3432984 A1 1985
[4] Rajadurai, R.; Analytical Chemistry: An Indian Journal 2010, V9(2), P265-269

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
C679Cefuroxime
C718Cefuroxime sodium

Current as of October 9, 2024


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CATEGORIES

 APIs and Bioactives > Antibacterials, Cephalosporins


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