43229-80-7 Formoterol hemifumarate AKSci C361
 
 
Loading Please Wait...
  C361    AKSci Reference Standard
Formoterol hemifumarate, 99% (HPLC)
 



IDENTITY
CAS Number:43229-80-7
MDL Number:MFCD03093863
MF:(C19H24N2O4)2.C4H4O4
MW:804.89
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC)
Spectra:FT-IR, LCMS, HPLC
Physical Form:White to beige powder or crystalline powder
Melting Point:136-142°C
Long-Term Storage:Store long-term at -20°C

BIOLOGICAL INFO
Solubility:DMSO: 20 mg/mL
Application(s):long-acting ß2 agonist (LABA)
Form:Fumarate salt

REVIEW
 The pharmacologic effects of beta2-adrenoceptor agonist drugs, including formoterol, are at least in part attributable to stimulation of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3'', 5''-adenosine monophosphate (cyclic AMP). Increased cyclic AMP levels cause relaxation of bronchial smooth muscle and inhibits the release of pro-inflammatory mast-cell mediators such as histamine and leukotrienes. Formoterol also inhibits histamine-induced plasma albumin extravasation in anesthetized guinea pigs and inhibits allergen-induced eosinophil influx in dogs with airway hyper-responsiveness. The relevance of these in vitro and animal findings to humans is unknown.

REFERENCES
[1]Bartow RA, Brogden RN: Formoterol. An update of its pharmacological properties and therapeutic efficacy in the management of asthma. Drugs. 1998 Feb;55(2):303-22.
[2] Cheer SM, Scott LJ: Formoterol: a review of its use in chronic obstructive pulmonary disease. Am J Respir Med. 2002;1(4):285-300.
[3] Steiropoulos P, Tzouvelekis A, Bouros D: Formoterol in the management of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2008;3(2):205-15.
[4] Faulds D, Hollingshead LM, Goa KL: Formoterol. A review of its pharmacological properties and therapeutic potential in reversible obstructive airways disease. Drugs. 1991 Jul;42(1):115-37.

GHS

Pictograms

Signal Word
None

Hazard Statements
None

Precautionary Statements
Not available

RELATED PRODUCTS
C361Formoterol hemifumarate
K252Formoterol
P2526-Guanidinohexanoic acid

Current as of July 10, 2020

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS

For research use only. Not for diagnostic or therapeutic use. Not for human use. AK Scientific, Inc. does not sell to individuals. If you are a first-time customer, please email for review at least two official business documents issued by your local jurisdiction, state/province, or country.


CATEGORIES
 APIs and Bioactives > Beta Blockers


PubChem