790299-79-5 Masitinib AKSci A821
 
 
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  A821    AKSci Reference Standard
Masitinib
, 98% (HPLC), powder
 
Masivet




IDENTITY
CAS Number:790299-79-5
MDL Number:MFCD09954132
MF:C28H30N6OS
MW:498.64
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC), powder
Physical Form (at 20°C):Solid
Density:1.3
Refractive Index:1.68
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 100mg/mL; H2O: <1mg/mL; EtOH: 4mg/mL
Application(s):Tyrosine kinases inhibitor for c-Kit, PDGFR, and FGFR.
Form:Free Base

REVIEW

 Masitinib is a targeted therapy that functions as a receptor tyrosine kinase inhibitor. This small molecule drug inhibits cell signaling by blocking the transfer of phosphate groups at the cell membrane. Masitinib has antitumor properties by selectively inhibiting KIT (also known as stem cell factor) which is a receptor known to be mutated or overactive in many mast cell tumors. Masitinib has antiangiogenic properties through its inhibition of platelet derived growth factor receptor. Interestingly, Masitinib also targets Lyn and Fak, key components of the transduction pathway leading to IgE induced degranulation. This effect expands the possible utility of Masitinib to include atopic disease, an area that has recently completed a clinically successful phase III study.

REFERENCES
[1]Lublin FD, Reingold SC: Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis.
[2] Confavreux C, Vukusic S, Moreau T, Adeleine P: Relapses and progression of disability in multiple sclerosis.
[3] Thompson AJ, Polman CH, Miller DH, McDonald WI, Brochet B, Filippi MMX, De Sa J: Primary progressive multiple sclerosis.
[4] Dubreuil P, Letard S, Ciufolini M, Gros L, Humbert M, Casteran N, Borge L, Hajem B, Lermet A, Sippl W, et al.: Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
A821Masitinib
3415AHMasitinib mesylate

Current as of October 6, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Protein Kinase Inhibitors


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