98105-99-8 Sarafloxacin AKSci A643
 
 
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  A643    
Sarafloxacin
, 98% (HPLC)
 
A-56620




IDENTITY
CAS Number:98105-99-8
MDL Number:MFCD00865974
MF:C20H17F2N3O3
MW:385.36
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Physical Form:White to light yellow powder
Melting Point:>300°C
Long-Term Storage:Store at room temperature

REVIEW

 Sarafloxacin is a fluoroquinoline antibacterial effective against Mycobacterium tuberculosis once used for prophylactic dosage in poultry and fish, as well as for normal use in human. The compound has shown multimodal mechanism of action and inhibits both DNA gyrase and topoisomerase IV enzyme, leading to increased antibacterial spectrum via DNA gyrase-dependent processes such as DNA polymerization, (ATP-dependent) DNA supercoiling, and chromosome fragmentation. Sarafloxacin was removed from clinical use by the manufacturer (Abbott Laboratories) on April 30, 2001 due to lack of sales.

REFERENCES
[1]Stamm JM, Hanson CW, Chu DT, Bailer R, Vojtko C, Fernandes PB. In vitro evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones. Antimicrob Agents Chemother. 1986 Feb;29(2):193-200.
[2] Fernandes PB, Chu DT, Bower RR, Jarvis KP, Ramer NR, Shipkowitz N. In vivo evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones. Antimicrob Agents Chemother. 1986 Feb;29(2):201-8.
[3] Smith BR, LeFrock JL, Donato JB, Joseph WS, Weber SJ. In vitro activity of A-56619 and A56620, two new aryl-fluoroquinolone antimicrobial agents. Antimicrob Agents Chemother. 1986 Feb;29(2):355-8.
[4] J.F. Bauer, et al.; Determination of temafloxacin, sarafloxacin, and difloxacin in bulk drug and dosage forms by high-performance liquid chromatography. Pharm. Res. 7, 1177 (1990)..

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


RELATED PRODUCTS
A643Sarafloxacin
S303Sarafloxacin hydrochloride

Current as of August 21, 2019


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Antibacterials, Quinolones, Veterinary


PubChem
  @PubMed