(2S)-2-Amino-4-((3R)-4-((3-fluorophenyl)(4-fluorophenyl)-methyl)-3-methylpiperazin-1-yl)-1-(isoindolin-2-yl)butane-1,4-dione AKSci Y0482
 
 
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  Y0482    
(2S)-2-Amino-4-((3R)-4-((3-fluorophenyl)(4-fluorophenyl)-methyl)-3-methylpiperazin-1-yl)-1-(isoindolin-2-yl)butane-1,4-dione
, 98%
 



IDENTITY
MDL Number:MFCD24848693
MF:C30H32F2N4O2
MW:518.6
SPECIFICATIONS & PROPERTIES
Purity:98%
Long-Term Storage:Store at room temperature

REVIEW

 C-Alkylation of the piperazine in AKSci cat# Y0432 results in increased DPP8 selectivity over DPP9.

REFERENCES
[1]Van Goethem, S., Matheeussen, V., Joossens, J., Lambeir, A.-M., Chen, X., De Meester, I., Haemers, A., Augustyns, K., and Van der Veken, P. (2011) Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal? J. Med. Chem. 54, 5737-5746.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of March 23, 2019


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CATEGORIES

 Chiral Synthesis >