603139-19-1 Odanacatib AKSci Y0388
 
 
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  Y0388    
Odanacatib, 99% (HPLC)
 
MK-0822
IDENTITY
CAS Number:603139-19-1
MDL Number:MFCD11042419
MF:C25H27F4N3O3S
MW:525.56
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:213-215°C
Density:1.4
Refractive Index:1.56
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO =102mg/mL, Water <1.2mg/mL, Ethanol =2.9mg/mL
Application(s):Cathepsin K
Form:Free Base
Research Area:Neurological disease

REVIEW
 Odanacatib (MK 0822) is an inhibitor of cathepsin K with potential anti-osteoporotic activity. Odanacatib selectively binds to and inhibits the activity of cathepsin K (IC50=0.2nM), which may result in a reduction in bone resorption, improvement of bone mineral density, and a reversal in osteoporotic changes. Odanacatib is currently in clinical development for the treatment of postmenopausal osteoporosis.

REFERENCES
[1]Sun L, Forni S, Schwartz MS, Breidinger S, Woolf EJ.Quantitative determination of odanacatib in human plasma using liquid-liquid extraction followed by liquid chromatography-tandem mass spectrometry analysis.J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Feb 15;885-886:15-23. Epub 2011 Dec 13.
[2] Khosla S.Odanacatib: location and timing are everything.J Bone Miner Res. 2012 Mar;27(3):506-8.
[3] Langdahl B, Binkley N, Bone H, Gilchrist N, Resch H, Portales JR, Denker A, Lombardi A, De Tilleghem CL, Dasilva C, Rosenberg E, Leung A.Odanacatib in the treatment of postmenopausal women with low bone mineral density: 5 years of continued therapy in a phase 2 study.J Bone Miner Res. 2012 Jul 6.
[4] Ng KW.Potential role of odanacatib in the treatment of osteoporosis.Clin Interv Aging. 2012;7:235-47. Epub 2012 Jul 12.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H372; H302; H315; H335; H319

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 20, 2024


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