REVIEW 6,8-Bis(benzylthio)octanoic acid is an lipoic acid based anti-tumor agent, an E1a pyruvate dehydrogenase (PDH) modulator, that prevents cancer cells from metabolizing glucose for energy. Further, 6,8-Bis(benzylthio)octanoic acid shows strong antitumor activity in vivo against human non-small cell lung and pancreatic cancers in xenograft models with low side-effect toxicity.
REFERENCES
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Gibson, Frank S.; Gupta, Deepak; Shorr, Robert; Rodriguez, Robert. An Efficient, Economical Synthesis of the Novel Anti-tumor Agent CPI-613. Organic Process Research & Development. (2011) 15(4): 855-857.
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Lee, King C.; Maturo, Claudia; Shorr, Robert; Rodriguez, Robert. Uncommon toxicologic profile at toxic doses of CPI-613 (an agent selectively alters tumor energy metabolism) in rats and minipigs reflects novel mechanism. American Journal of Pharmacology and Toxicology. (2010) 5(4): 183-208.
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Lee KC, Shorr R, Rodriguez R, Maturo C, Boteju LW, Sheldon A. Formation and anti-tumor activity of uncommon in vitro and in vivo metabolites of CPI-613, a novel anti-tumor compound that selectively alters tumor energy metabolism. Drug Metab Lett. (2011) 5(3): 163-82.
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Shorr, Robert G.L.; Rodriguez, Robert J.; Bhasin, Rajinder Pharmaceutical formulations containing lipoic acid derivatives such as bis(benzyl) lipoate, and ion pairing agent U.S. Pat. Appl. Publ. (2008), US 20080262077 A1 20081023.
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