742112-33-0 OSU-03012 AKSci Y0267
 
 
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  Y0267    AKSci Reference Standard
OSU-03012
, 98% (HPLC), powder
 
2-Amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide




IDENTITY
CAS Number:742112-33-0
MDL Number:MFCD12912272
MF:C26H19F3N4O
MW:460.45
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC), powder
Spectra:LCMS, HPLC
Physical Form:White powder
Melting Point:177-180°C
Long-Term Storage:Store long-term at -20°C

BIOLOGICAL INFO
Solubility:DMSO
Application(s):PDK
Form:Free base
Research Area:Cancer

REVIEW

 OSU-03012 is an analog of celecoxib that exhibits anti-cancer activity in a COX-2-independent manner via inhibition of the phosphatidyl inositol-3-kinase/Akt pathway. It is a potent inhibitor of tumor cell growth and induces apoptosis of chronic lymphocytic leukemia cells independent of bcl-2 overexpression using both caspase-dependent and independent pathways.

REFERENCES
[1]Porchia LM, Guerra M, Wang YC, Zhang Y, Espinosa AV, Shinohara M, Kulp SK, Kirschner LS, Saji M, Chen CS, Ringel MD. 2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a celecoxib derivative, directly targets p21-activated kinase. Mol Pharmacol. (2007) Nov;72(5): 1124-31.
[2] Zhang S, Suvannasankha A, Crean CD, White VL, Johnson A, Chen CS, Farag SS. OSU-03012, a novel celecoxib derivative, is cytotoxic to myeloma cells and acts through multiple mechanisms. Clin Cancer Res. (2007) Aug 15;13(16): 4750-8.
[3] McCubrey, James A.; LaHair, Michelle M.; Franklin, Richard A. OSU-03012 in the treatment of glioblastoma. Molecular Pharmacology. (2006) 70(2): 437-439.
[4] Zhu, Jiuxiang; Huang, Jui-Wen; Tseng, Ping-Hui; Yang, Ya-Ting; Fowble, Joseph; Shiau, Chung-Wai; Shaw, Yeng-Jeng; Kulp, Samuel K.; Chen, Ching-Shih From the Cyclooxygenase-2 Inhibitor Celecoxib to a Novel Class of 3-Phosphoinositide-Dependent Protein Kinase-1 Inhibitors Cancer Research (2004), 64(12), 4309-4318

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 19, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


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