711019-86-2 MRS-2578 AKSci Y0242
 
 
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  Y0242    AKSci Reference Standard
MRS-2578, 95%
 
1,4-Di[3-(3-isothiocyanatophenyl)thioureido]butane
IDENTITY
CAS Number:711019-86-2
MDL Number:MFCD07370141
MF:C20H20N6S4
MW:472.67
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply to certain package sizes and shipment methods. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Solubility:DMSO: >5 mg/mL

REVIEW
 MRS-2578 is a symmetric aryl diisothiocyanate derivative, which has been shown to be an inhibitor of P2Y receptors. It is a selective antagonist of P2Y6 nucleotide receptors that Inhibits agonist-induced cardiomyocyte contraction and UDP-induced phagocytosis.

REFERENCES
[1]Mamedova, Liaman K.; Joshi, Bhalchandra V.; Gao, Zhan-Guo; von Kugelgen, Ivar; Jacobson, Kenneth A. Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. Biochemical Pharmacology. (2004) 67(9): 1763-1770.
[2] Tsukimoto M, Tokunaga A, Harada H, Kojima S. Blockade of murine T cell activation by antagonists of P2Y6 and P2X7 receptors. Biochem Biophys Res Commun. (2009) Jul 10;384(4): 512-8.
[3] Ko T, An HJ, Ji YG, Kim OJ, Lee DH. P2Y receptors regulate proliferation of human pancreatic duct epithelial cells. Pancreas. (2012) Jul;41(5): 797-80.
[4] Talasila A, Germack R, Dickenson JM.Characterization of P2Y receptor subtypes functionally expressed on neonatal rat cardiac myofibroblasts. Br J Pharmacol. 2009 Sep;158(1):339-53

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301; H312+H332; H315; H319; H334; H335

Precautionary Statements
P261; P264; P270; P271; P280; P285; P301+P310; P302+P352; P304+P340; P305+P351+P338; P322; P330; P332+P313; P337+P313; P342+P311; P362; P403+P233; P405; P501

Current as of September 21, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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