REVIEW Columbianetin, an optically benzopyran is one of the main active constituents isolated from the roots of Angelica pubescens Maxim. f. biserrata Shan et Yuan (RAP) which has been used as a traditional Chinese medicine to treat rheumatic disease in China since ancient times,and has been shown to have anti-inflammatory activities. Mechanistically, Columbianetin inhibited expression of COX-2, and inhibited the histamine release by substance P, and show Columbianetin may be helpful in regulating mast cell-mediated allergic inflammatory responses.
REFERENCES
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Willette, Robert E.; Soine, Taito O Coumarins. II. Structures of columbianadin and columbianin. Journal of Pharmaceutical Sciences (1964), 53(3), 275-9.
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Li RZ, He YQ, Chiao M, Xu Y, Zhang QB, Meng JR, Gu Y, Ge LP. Studies of the active constituents of the Chinese drug duhuo Angelica pubescents. Yao Xue Xue Bao. 1989;24(7):546-51.
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Jeong HJ, Na HJ, Kim SJ, Rim HK, Myung NY, Moon PD, Han NR, Seo JU, Kang TH, Kim JJ, Choi Y, Kang IC, Hong SH, Kim YA, Seo YW, Kim HM, Um JY, Anti-inflammatory effect of Columbianetin on activated human mast cells. Biol Pharm Bull. 2009 Jun;32(6):1027-31.
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