328543-09-5 AG14361 AKSci X7542
 
 
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  X7542    
AG14361
, 99% (HPLC)
 
Imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one, 2-[4-[(dimethylamino)methyl]phenyl]-5,6-dihydro-




IDENTITY
CAS Number:328543-09-5
MDL Number:MFCD18385009
MF:C19H20N4O
MW:320.39
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC)
Spectra:NMR, LCMS, HPLC
Physical Form:Light yellow to orange to beige powder
Melting Point:216-218°C
Long-Term Storage:Store long-term at 2-8°C

BIOLOGICAL INFO
Solubility:DMSO
Application(s):PARP
Form:Free Base
Research Area:Cancer

REVIEW

 AG14361 is a potent poly(ADP-ribose) polymerase (PARP-1) inhibitor with a GI50 of 10.9 µM.

REFERENCES
[1]Tsuda M, Tanaka M, Mushiake M, Takahashi J, Tanaka K, Watase J, Fujisawa J, Miwa M.Novel pathway of centrosome amplification that does not require DNA lesions.Cancer Sci. 2012 Feb;103(2):191-6.
[2] Golla RM, Li M, Shen Y, Ji M, Yan Y, Fu K, Greiner TC, McKeithan TW, Chan WC.Inhibition of poly(ADP-ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks.Hematol Oncol. 2011 Dec 14.
[3] Calabrese CR, Almassy R, Barton S, Batey MA, Calvert AH, Canan-Koch S, Durkacz BW, Hostomsky Z, Kumpf RA, Kyle S, Li J, Maegley K, Newell DR, Notarianni E, Stratford IJ, Skalitzky D, Thomas HD, Wang LZ, Webber SE, Williams KJ, Curtin NJ.Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.J Natl Cancer Inst. 2004 Jan 7;96(1):56-67.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of August 19, 2019


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CATEGORIES

 APIs and Bioactives > Polymerase Inhibitors


PubChem