REVIEW AG14361 is a potent poly(ADP-ribose) polymerase (PARP-1) inhibitor with a GI50 of 10.9 µM.
Tsuda M, Tanaka M, Mushiake M, Takahashi J, Tanaka K, Watase J, Fujisawa J, Miwa M.Novel pathway of centrosome amplification that does not require DNA lesions.Cancer Sci. 2012 Feb;103(2):191-6.
Golla RM, Li M, Shen Y, Ji M, Yan Y, Fu K, Greiner TC, McKeithan TW, Chan WC.Inhibition of poly(ADP-ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks.Hematol Oncol. 2011 Dec 14.
Calabrese CR, Almassy R, Barton S, Batey MA, Calvert AH, Canan-Koch S, Durkacz BW, Hostomsky Z, Kumpf RA, Kyle S, Li J, Maegley K, Newell DR, Notarianni E, Stratford IJ, Skalitzky D, Thomas HD, Wang LZ, Webber SE, Williams KJ, Curtin NJ.Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.J Natl Cancer Inst. 2004 Jan 7;96(1):56-67.
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