852808-04-9 ABT-737 AKSci X7536
 
 
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  X7536    
ABT-737, 98% (HPLC)
 
4-{4-[(4ʹ-Chlorobiphenyl-2-yl)methyl]piperazin-1-yl}-N-{[4-({(1R)-3-(dimethylamino)-1-[(phenylsulfanyl)methyl]propyl}amino)-3-nitrophenyl]sulfonyl}benzamide
IDENTITY
CAS Number:852808-04-9
MDL Number:MFCD12756212
MF:C42H45ClN6O5S2
MW:813.43
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:150-160°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO>163mg/mL, Water<1mg/mL, Ethanol<1mg/mL
Application(s):BH3 mimetic inhibitor; Bcl-2
Form:Free base
Research Area:Leukemia

REVIEW
 ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 µM (Nalm-6, K562 and HL-60).

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 19, 2024


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