49843-98-3 EX-527 AKSci X7534
 
 
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  X7534    
EX-527, 98% (HPLC)
 
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
IDENTITY
CAS Number:49843-98-3
MDL Number:MFCD03009471
MF:C13H13ClN2O
MW:248.71
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:181-184°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: >20 mg/mL
Application(s):A selective inhibitor of SIRT1 over SIRT2 and SIRT3
Form:Free Base

REVIEW
 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide is a potent and selective deacetylase sirtin 1 (SIRT1) inhibitor that has shown benefit across a range of preclinical models for Huntingdon''s Disease. The compound has become a useful tool for studying the relationship between SIRT1 and cell regulation as well as a potential agent for the treatment of Huntington's Disease.

REFERENCES
[1]Sakkiah, Sugunadevi; Baek, Ayoung; Lee, Keun Woo. Pharmacophore modeling and molecular dynamics simulation to identify the critical chemical features against human sirtuin 2 inhibitors. Journal of Molecular Structure. (2012) 1011: 66-75.
[2] Napper, Andrew D.; Hixon, Jeffrey; McDonagh, Thomas; Keavey, Kenneth; Pons, Jean-Francois; Barker, Jonathan; Yau, Wei Tsung; Amouzegh, Patricia; Flegg, Adam; Hamelin, Estelle; et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. Journal of Medicinal Chemistry. (2005) 48(25): 8045-8054.
[3] 'Smith MR, Syed A, Lukacsovich T, Purcell J, Barbaro BA, Worthge SA, Wei SR, Pollio G, Magnoni L, Scali C, Massai L, Franceschini D, Camarri M, Gianfriddo M, Diodato E, Thomas R, Gokce O, Tabrizi SJ, Caricasole A, Landwehrmeyer B, Menalled L, Murphy C, Ramboz S, Luthi-Carter R, Westerberg G, Marsh JL. A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington''s disease. Hum Mol Genet. (2014) Jan 29.'
[4] Dostert, Philippe; Kyburz, Emilio Aminoalkyltetrahydrocarbazoles Ger. Offen. (1973), DE 2263682 A1 19730705.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301; H319

Precautionary Statements
P264; P270; P280; P301+P310; P305+P351+P338; P321; P330; P337+P313; P405; P501

Current as of September 19, 2024


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