49843-98-3 EX-527 AKSci X7534
 
 
Loading Please Wait...
  X7534    
EX-527
, 98% (HPLC)
 
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide




IDENTITY
CAS Number:49843-98-3
MDL Number:MFCD03009471
MF:C13H13ClN2O
MW:248.71
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:181-184°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: >20 mg/mL
Application(s):A selective inhibitor of SIRT1 over SIRT2 and SIRT3
Form:Free Base

REVIEW

 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide is a potent and selective deacetylase sirtin 1 (SIRT1) inhibitor that has shown benefit across a range of preclinical models for Huntingdon''s Disease. The compound has become a useful tool for studying the relationship between SIRT1 and cell regulation as well as a potential agent for the treatment of Huntington's Disease.

REFERENCES
[1]Sakkiah, Sugunadevi; Baek, Ayoung; Lee, Keun Woo. Pharmacophore modeling and molecular dynamics simulation to identify the critical chemical features against human sirtuin 2 inhibitors. Journal of Molecular Structure. (2012) 1011: 66-75.
[2] Napper, Andrew D.; Hixon, Jeffrey; McDonagh, Thomas; Keavey, Kenneth; Pons, Jean-Francois; Barker, Jonathan; Yau, Wei Tsung; Amouzegh, Patricia; Flegg, Adam; Hamelin, Estelle; et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. Journal of Medicinal Chemistry. (2005) 48(25): 8045-8054.
[3] 'Smith MR, Syed A, Lukacsovich T, Purcell J, Barbaro BA, Worthge SA, Wei SR, Pollio G, Magnoni L, Scali C, Massai L, Franceschini D, Camarri M, Gianfriddo M, Diodato E, Thomas R, Gokce O, Tabrizi SJ, Caricasole A, Landwehrmeyer B, Menalled L, Murphy C, Ramboz S, Luthi-Carter R, Westerberg G, Marsh JL. A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington''s disease. Hum Mol Genet. (2014) Jan 29.'
[4] Dostert, Philippe; Kyburz, Emilio Aminoalkyltetrahydrocarbazoles Ger. Offen. (1973), DE 2263682 A1 19730705.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301; H319

Precautionary Statements
P264; P270; P280; P301+P310; P305+P351+P338; P321; P330; P337+P313; P405; P501


Current as of September 19, 2024


Download SDS Request COA

All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.



CATEGORIES

 APIs and Bioactives >


PubChem