540737-29-9 Tofacitinib citrate AKSci X7518
Loading Please Wait...
  X7518    AKSci Reference Standard
Tofacitinib citrate
, 98%

CAS Number:540737-29-9
MDL Number:MFCD11616529
Min. Purity Spec:98%
Physical Form (at 20°C):Solid
Melting Point:214-218°C (subl.)
Long-Term Storage:Store long-term at -20°C
Not hazardous material



 Tofacitinib (CP-690,550; CP-690550; CP690550), an orally active immunosuppressant, is being developed by Pfizer for the treatment of rheumatoid arthritis, inflammatory bowel disease, dry eyes, ankylosing spondylitis, psoriasis, psoriatic arthritis, and for the prevention of transplant rejection. Tofacitinib specifically inhibits Janus activated kinase 3 (JAK3), which has a pivotal role in cytokine signal transduction that governs lymphocyte survival, proliferation, differentiation, and apoptosis. It is currently approved for the treatment of rheumatoid arthritis (RA) in the United States and is being studied for treatment of psoriasis, inflammatory bowel disease, and other immunological diseases, as well as for the prevention of organ transplant rejection. Tofacitinib was not approved by the European regulatory agencies because of concerns over efficacy and safety.

[1]Flanagan, Mark Edward; Li, Zheng Jane, Preparation of a novel crystalline compound useful as inhibitors of protein kinases PCT Int. Appl. (2003), WO 2003048162 A1 20030612.
[2] Mark E. Flanagan, Todd A. Blumenkopf, William H. Brissette, Matthew F. Brown, Jeffrey M. Casavant, Chang Shang-Poa, Jonathan L. Doty, Eileen A. Elliott, Michael B. Fisher, Michael Hines, Craig Kent, Elizabeth M. Kudlacz, Brett M. Lillie, Kelly S. Magnuson, Sandra P. McCurdy, Michael J. Munchhof, Bret D. Perry, Perry S. Sawyer, Timothy J. Strelevitz, Chakrapani Subramanyam, Jianmin Sun, David A. Whipple, and Paul S. Changelian, Disocovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection, Journal of Medicinal Chemistry (2010), 53(24), 8468-8484.
[3] Kremer JM, Bloom BJ, Breedveld FC, Coombs JH, Fletcher MP, Gruben D, Krishnaswami S, Burgos-Vargas R, Wilkinson B, Zerbini CA, Zwillich SH. The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo. Arthritis Rheum. 2009 Jul;60(7):1895-905. doi: 10.1002/art.24567.
[4] West K. CP-690550, a JAK3 inhibitor as an immunosuppressant for the treatment of rheumatoid arthritis, transplant rejection, psoriasis and other immune-mediated disorders. Curr Opin Investig Drugs. 2009 May;10(5):491-504.



Signal Word

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of June 22, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.

Download SDS Request COA

All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.


 APIs and Bioactives >