REVIEW CI-1040 (PD 184352) is an ATP non-competitive MEK1/2 inhibitor of with IC50 of 17 nM. Small-molecule benzhydroxamate inhibitor blocks the phosphorylation of ERK.
REFERENCES
[1]
Barrett, Stephen Douglas; Bridges, Alexander James; Doherty, Annette Marian; Dudley, David Thomas; Saltiel, Alan Robert; Tecle, Haile Preparation of 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives as MEK inhibitors PCT Int. Appl. (1999), WO 9901426 A1 19990114.
[2]
Gilbertsen, Richard Buell Preparation of 2-(4-bromo or 4-iodo phenylamino)benzoic acid derivatives as MEK inhibitors PCT Int. Appl. (2000), WO 2000035435 A1 20000622.
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