212631-79-3 PD184352 AKSci X7396
 
 
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  X7396    AKSci Reference Standard
PD184352, 98% (HPLC)
 
CI-1040
2-(2-Chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
IDENTITY
CAS Number:212631-79-3
MDL Number:MFCD02683961
MF:C17H14ClF2IN2O2
MW:478.66
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:173-180°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO 96 mg/mL
Application(s):MEK1/2 inhibitor
Form:Free base

REVIEW
 CI-1040 (PD 184352) is an ATP non-competitive MEK1/2 inhibitor of with IC50 of 17 nM. Small-molecule benzhydroxamate inhibitor blocks the phosphorylation of ERK.

REFERENCES
[1]Barrett, Stephen Douglas; Bridges, Alexander James; Doherty, Annette Marian; Dudley, David Thomas; Saltiel, Alan Robert; Tecle, Haile Preparation of 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives as MEK inhibitors PCT Int. Appl. (1999), WO 9901426 A1 19990114.
[2] Gilbertsen, Richard Buell Preparation of 2-(4-bromo or 4-iodo phenylamino)benzoic acid derivatives as MEK inhibitors PCT Int. Appl. (2000), WO 2000035435 A1 20000622.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H410

Precautionary Statements
P273; P391; P501

Current as of December 26, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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