5142-23-4 3-Methyladenine AKSci X5709
 
 
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  X5709    
3-Methyladenine
, 98% (HPLC)
 
Autophagy Inhibitor, 3-MA
6-Amino-3-methylpurine, NSC 66389




IDENTITY
CAS Number:5142-23-4
MDL Number:MFCD00010531
MF:C6H7N5
MW:149.15
EINECS:225-908-6
BRN:146087
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:302-308°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):A multi-use inhibitor that protects cerebellar granule cells from apoptosis

REVIEW

 3-Methyladenine (3-MA) is used to inhibit and study the mechanism of autophagy (lysosomal self-degradation) and apoptosis under various conditions. 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). For use as an autophagy inhibitor, 3-MA is typically used at a concentration of 5 mM.

REFERENCES
[1]Stoller, C.; Journal of Natural Products 1988, V51(2), P383-4

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of June 30, 2022


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CATEGORIES

 Nucleobases > Purines


PubChem