895155-26-7 A-796260 AKSci X5014
 
 
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  X5014    AKSci Reference Standard
A-796260, 98% (HPLC)
 
[1-(2-Morpholin-4-ylethyl)-1H-indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone
IDENTITY
CAS Number:895155-26-7
MDL Number:MFCD22421643
MF:C22H30N2O2
MW:354.49
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:135-138°C
Density:1.161
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW
 A 796260 is a synthetic selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models. A 796260 demonstrated analgesic activity across multiple preclinical pain models. AM1241 is an indole derivative that exhibits high affinity and selectivity for the CB2 binding site and broad spectrum analgesic activity in rodent models, but is not an antagonist of CB2 in vitro functional assays. Additionally, its analgesic effects are opioid receptor-dependent.

REFERENCES
[1]Frost, Jennifer M.; Journal of Medicinal Chemistry 2010, V53(1), P295-315
[2] B B Yao, G C Hsieh, J M Frost, Y Fan, T R Garrison, A V Daza, G K Grayson, C Z Zhu, M Pai, P Chandran, A K Salyers, E J Wensink, P Honore, J P Sullivan, M J Dart, M D Meyer, In vitro and in vivo characterization of A-796260: a selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models, British Journal of Pharmacology (2008), 153(2), 390-401.
[3] Jennifer M. Frost, Michael J. Dart, Karin R. Tietje, Tiffany R. Garrison, George K. Grayson, Anthony V. Daza, Odile F. El-Kouhen, Betty B. Yao, Gin C. Hsieh, Madhavi Pai, Chang Z. Zhu, Prasant Chandran and Michael D. Meyer, Indol-3-ylcycloalkyl Ketones: Effects of N1 Substituted Indole Side Chain Variations on CB2 Cannabinoid Receptor Activity. J. Med. Chem., 2010, 53 (1), pp 295-315.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of May 8, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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