Soluble in water, dimethylsulfoxide and methanol. Slightly soluble in anhydrous ethanol. Insoluble in methylene chloride.
REVIEW Methylenediphosphonic acid is used as a radioactive imaging agent, which is primarily used in skeletal scintigraphy. Due to its absorption by a variety of tumors, it is useful for the detection of neoplasms.
Used as an analogue of inorganic pyrophosphate for preparation of analogues of natural di- and tri-phosphates. See, e.g.: J. Org. Chem., 44, 3997 (1979). Review: Chem. Rev., 77, 872 (1977).
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