6164-67-6 Pseudopelletierine oxime AKSci X3279
 
 
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  X3279    
Pseudopelletierine oxime
, 98% (HPLC)
 
N-(9-Methyl-9-azabicyclo[3.3.1]nonan-3-ylidene)hydroxylamine




IDENTITY
CAS Number:6164-67-6
MDL Number:MFCD03755545
MF:C9H16N2O
MW:168.24
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Spectra:LCMS, HPLC
Physical Form:Light yellow to light beige powder
Melting Point:126-130°C
Long-Term Storage:Store at room temperature
HAZARDOUS MATERIALS INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):5-HT3 antagonist

REVIEW

 Pseudopelletierine oxime, the oxime of 3-tropinone, is a key intermediate in the synthesis of Dolasetron (dolasetron mesilate) a 5-HT3 antagonist.

REFERENCES
[1]Putney, Blake F.; Soine, Taito O.; A synthesis of pseudopelletierine, Journal of the American Pharmaceutical Association (1912-1977) (1955), 44, 17-22.
[2] Hadley, Michael Stewart; King, Francis David Azabicycloalkyl derivatives and pharmaceutical compositions containing them. Eur. Pat. Appl. (1980), EP 13138 A1 19800709.
[3] Smith, Gillian Elizabeth. Process for the production of aminoazabicycloalkanes from oximes. PCT Int. Appl. (1996), WO 9603401 A2 19960208.
[4] Vernekar, Sanjeev Kumar V.; Hallaq, Hasan Y.; Clarkson, Guy; Thompson, Andrew J.; Silvestri, Linda; Lummis, Sarah C. R.; Lochner, Martin Toward Biophysical Probes for the 5-HT3 Receptor: Structure-Activity Relationship Study of Granisetron Derivatives. Journal of Medicinal Chemistry (2010), 53(5), 2324-2328.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of June 16, 2021


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CATEGORIES

 APIs and Bioactives > Alkaloids


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