503612-47-3 Apixaban AKSci X1060
 
 
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  X1060    AKSci Reference Standard
Apixaban
, 98% (HPLC)
 
BMS-562247




IDENTITY
CAS Number:503612-47-3
MDL Number:MFCD11977295
MF:C25H25N5O4
MW:459.5
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Physical Form:White crystalline powder
Melting Point:238-240°C
Density:1.4
Refractive Index:1.7
Long-Term Storage:Store long-term at -20°C

BIOLOGICAL INFO
Solubility:DMSO in 18 mg/mL Water in <1 mg/mL Ethanol in <1 mg/mL
Application(s):Reversible inhibitor of Factor Xa
Form:Free Base
Research Area:venous thromboembolism, stroke

REVIEW

 Apixaban is a highly selective, reversible, and direct inhibitor of Human Factor X and Rabbit Factor X with Ki of 0.08 nM and 0.17 nM, respectively. Apixaban exhibits a high degree of potency, selectivity, and efficacy on Factor X with Ki of 0.08 nM and 0.17 nM for Human Factor X and Rabbit Factor X, respectively. In vitro, Apixaban prolongs the clotting times of normal human plasma with the concentrations (EC2x) of 3.6 µM, 0.37 µM, 7.4 µM, and 0.4 µM, which are required respectively to double the prothrombin time (PT), modified prothrombin time (mPT), activated partial thromboplastin time (APTT) and HepTest. Besides, Apixaban shows the highest potency in human and rabbit plasma, but less potency in rat and dog plasma in both the PT and APTT assays.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of September 19, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


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