89396-94-1, 89371-37-9 Imidapril hydrochloride AKSci X1042
 
 
Loading Please Wait...
  X1042    AKSci Reference Standard
Imidapril hydrochloride, 98% (HPLC), powder
 
(4S)-3-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4-imidazolidinecarboxylic acid hydrochloride
IDENTITY
CAS Number:89396-94-1, 89371-37-9
MDL Number:MFCD00923828
MF:C20H28ClN3O6
MW:441.91
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:218-224°C
Optical Rotation:-50 to -70° in ethanol (c=0.5)
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:H2O: 5 mg/mL
Application(s):Angiotensin-converting enzyme (ACE) inhibitor

REVIEW
 'Imidapril is a long-acting, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor, which has been used clinically in the treatment of hypertension, chronic congestive heart failure (CHF), acute myocardial infarction (AMI), and diabetic nephropathy. It has the unique advantage over other ACE inhibitors in causing a lower incidence of dry cough. Imidapril (Tanatril), the (S,S,S) optically active isomer is active through its active metabolite imidaprilat, which acts as an ACE inhibitor to suppress the conversion of angiotensin I to angiotensin II and thereby reduce total peripheral resistance and systemic blood pressure (BP). In clinical trials, oral imidapril was an effective antihypertensive agent in the treatment of mild to moderate essential hypertension. chronic congestive heart failure (CHF), acute myocardial infarction (AMI), and diabetic nephropathy.'

REFERENCES
[1]Kubota H; Nunami K; Hayashi K; Hashimoto Y; Ogiku N; Matsuoka Y; Ishida R Studies on angiotensin converting enzyme inhibitors. VI. Synthesis and angiotensin converting enzyme inhibitory activities of the dicarboxylic acid derivative of imidapril and its diastereoisomers. Chemical & pharmaceutical bulletin (1992), 40(6), 1619-22.
[2] Robinson DM, Curran MP, Lyseng-Williamson KA. Imidapril: a review of its use in essential hypertension, Type 1 diabetic nephropathy and chronic heart failure. Drugs. 2007;67(9):1359-78.
[3] Dolezal T. Imidapril in heart failure. J Renin Angiotensin Aldosterone Syst. 2006 Sep;7(3):146-54.
[4] Robinson DM, Curran MP, Lyseng-Williamson KA. Imidapril: a review of its use in essential hypertension, Type 1 diabetic nephropathy and chronic heart failure. Drugs. 2007;67(9):1359-78.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of October 1, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS Request COA

⚠️
These chemical products are for research and development use only. They are not for diagnostic, therapeutic, cosmetic, or human and animal uses. They are not sold to individuals. Additional restrictions may apply.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information.

CATEGORIES
 APIs and Bioactives > ACE Inhibitors, Hypertension


PubChem
  @PubMed