REVIEW Butein is a naturally occurring chalconoid found in Toxicodendron vernicifluum (or formerly Rhus verniciflua) and has beeb used as a traditional herbal medicine for its various biological activities. These include antioxidative, aldose reductase, advanced glycation endproducts inhibitory effects, suppression of NH-kappaB mediated inflammation and cancer.and anti-adipogenic effects It is also a sirtuin-activating compound, a chemical compound having an effect on sirtuins, a group of enzymes that use NAD+ to remove acetyl groups from proteins. They are caloric restriction mimetic candidates, molecules able to prevent aging-related diseases like Alzheimer's, diabetes, and obesity.
Lee EH, Song DG, Lee JY, Pan CH, Um BH, Jung SH. Inhibitory effect of the compounds isolated from Rhus verniciflua on aldose reductase and advanced glycation endproducts. Biol Pharm Bull. 2008 Aug;31(8):1626-30.
Wang Y. The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase. Life Sci. 2005 May 20;77(1):39-51.
Gupta SC, Kim JH, Prasad S, Aggarwal BB. Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Rev. 2010 Sep;29(3):405-34.
Yadav VR, Prasad S, Sung B, Aggarwal BB. The role of chalcones in suppression of NF-kappaB-mediated inflammation and cancer. Int Immunopharmacol. 2011 Mar;11(3):295-309
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