602-41-5 Thiocolchicoside AKSci W0078
 
 
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  W0078    AKSci Reference Standard
Thiocolchicoside
, 99% (HPLC)
 
Coltramyl
Musco-ril
10-Thiocolchicoside
more..




IDENTITY
CAS Number:602-41-5
MDL Number:MFCD07995056
MF:C27H33NO10S
MW:563.62
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC)
Spectra:LCMS, HPLC, Polarimetry
Physical Form:Yellow powder
Melting Point:208-213°C
Optical Rotation:-609° (c=1, H2O)
Long-Term Storage:Store long-term at 2-8°C

BIOLOGICAL INFO
Application(s):Competitive GABAA receptor antagonist and also glycine receptor antagonist

REVIEW

 Thiocolchicoside is a small molecule muscle relaxant and anti-inflammatory agent, shown to function as a competitive gamma-aminobutyric acid type A (GABAA) receptor antagonist. Thiocolchicoside is also shown to inhibit strychnine-sensitive glycine receptors with lower potency than GABAA, and to inhibit human nicotinic acetylcholine receptors with very low relative affinity.

REFERENCES
[1] Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010)
[2] Gelmi, M., et al.: J. Med. Chem., 50, 2245 (2007)
[3] Mascia, M., et al.: Eur. J. Pharmacol., 558, 37 (2007)

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of August 22, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Muscle Relaxants


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