A hazmat fee may apply to certain package sizes. Please check pricing table for an indicator of applicable hazmat fees.
BIOLOGICAL INFO
Solubility:
DMSO
Application(s):
HDAC1 and HDAC3 inhibitor
Form:
Free base
Research Area:
Cancer
REVIEW Entinostat, also known as SNDX-275 and MS-275, is a benzamide histone deacetylase inhibitor undergoing clinical trials for treatment of various cancers. Entinostat inhibits class I HDAC1 and HDAC3 with IC50 of 0.51uM and 1.7 uM, respectively. Entinostat is a well-tolerated HDAC inhibitor that demonstrates promising therapeutic potential in both solid and hematologic malignancies. Histone deacetylases (EC 3.5.1.98, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an epsilon-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and deacetylation
REFERENCES
[1]
Hess-Stumpp H, Bracker TU, Henderson D, Politz O. MS-275, a potent orally available inhibitor of histone deacetylases--the development of an anticancer agent. Int J Biochem Cell Biol. 2007;39(7-8):1388-405.
[2]
Bracker TU, Sommer A, Fichtner I, Faus H, Haendler B, Hess-Stumpp H. fficacy of MS-275, a selective inhibitor of class I histone deacetylases, in human colon cancer models. Int J Oncol. 2009 Oct;35(4):909-20.
[3]
Knipstein J, Gore L. Einostat for treatment of solid tumors and hematologic malignancies. Expert Opin Investig Drugs. 2011 Oct;20(10):1455-67.
All products are stocked and shipped from San Francisco Bay Area, California, USA.
⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.
These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.
Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
Add to Favorites 
Delete from Favorites 
