159351-69-6 Everolimus AKSci V2036
 
 
Loading Please Wait...
  V2036    AKSci Reference Standard
Everolimus
, 98% (HPLC), powder
 
Afinitor
Certican
Zortress
more..




IDENTITY
CAS Number:159351-69-6
MDL Number:MFCD00929329
MF:C53H83NO14
MW:958.22
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:97-101°C
Density:1.18
Refractive Index:1.55
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 30 mg/ml; H2O: <1 mg/ml; Ethanol 7 mg/ml
Application(s):mTOR inhibitor
Form:Free Base
Research Area:tuberous sclerosis,neuroendocrine tumours,cancer

REVIEW

 Everolimus is a mTOR inhibitor that binds with high affinity to the FK506 binding protein-12 (FKBP-12), thereby forming a drug complex that inhibits the activation of mTOR. This inhibition reduces the activity of effectors downstream, which leads to a blockage in the progression of cells from G1 into S phase, and subsequently inducing cell growth arrest and apoptosis. Everolimus also inhibits the expression of hypoxia-inducible factor, leading to a decrease in the expression of vascular endothelial growth factor. The result of everolimus inhibition of mTOR is a reduction in cell proliferation, angiogenesis, and glucose uptake.

REFERENCES
[1]Kuhn B, Jacobsen W, Christians U, Benet LZ, Kollman PA: Metabolism of sirolimus and its derivative everolimus by cytochrome P450 3A4: insights from docking, molecular dynamics, and quantum chemical calculations. J Med Chem. 2001 Jun 7;44(12):2027-34.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H372; H412

Precautionary Statements
P260; P264; P270; P273; P314; P501


Current as of September 29, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS Request COA

⚠️
These chemical products are for research and development use only. They are not for diagnostic, therapeutic, cosmetic, or human and animal uses. They are not sold to individuals. Additional restrictions may apply.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information.


CATEGORIES

 APIs and Bioactives > Immunomodulators


PubChem