912-60-7 Noscapine hydrochloride AKSci V1623
 
 
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  V1623    
Noscapine hydrochloride
 



IDENTITY
CAS Number:912-60-7
MDL Number:MFCD00082546
MF:C22H23NO7.HCl
MW:449.89
EINECS:213-014-9
SPECIFICATIONS & PROPERTIES
Physical Form:White powder
Melting Point:221-223°C
Refractive Index:1.6
Long-Term Storage:Store long-term at -20°C

BIOLOGICAL INFO
Solubility:Soluble in water, and 1eq. HCl (50 mM)
Application(s):A bradykinin B and tubulin inhibitor

REVIEW

 Noscapine hydrochloride is the hydrochloride form of Noscapine. Noscapine is an opioid alkaloid with several actions. Antagonist at Bradykinin B Receptor (bradykinin receptors) (pA2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated cAMP increases in CNS tissues. Additionally Noscapine binds to tubulin, arrests cells in mitosis and induces apoptosis. Blocks proliferation of human leukemia and multiple myeloma cells. Furthermore, Noscapine modulates IKK activation, suppressing the NF-κB signaling pathway. Exhibits anti-inflammatory activity. Noscapine hydrochloride is an inhibitor of Tubulin. IC50 data: CYP2C19: IC50 = 400.3 nM (human); HepG2: IC50 >1000 nM (human); A549: EC5050 = 25 μM (human)

REFERENCES
[1]Mourey, R.J., et al. 1992. Mol. Pharmacol. 42: 619-626.
[2] Ye, K., et al. 1998. Proc. Natl. Acad. Sci. U.S.A. 95: 1601-1606.
[3] Mahmoudian, M. and Mojaverian, M. 2001. Acta Physiol. Hung. 88: 231-237.
[4] Landen, J.W., et al. 2002. Cancer Res. 62: 4109-4114.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312+P330; P501


Current as of June 3, 2020


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Alkaloids


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