161796-78-7 Esomeprazole sodium AKSci V1577
 
 
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  V1577    AKSci Reference Standard
Esomeprazole sodium
, >98% (HPLC), powder
 
Nexium




IDENTITY
CAS Number:161796-78-7
MDL Number:MFCD07802816
MF:C17H20N3NaO3S
MW:369.41
SPECIFICATIONS & PROPERTIES
Purity:>98% (HPLC), powder
Spectra:NMR, LCMS, HPLC
Physical Form:White powder
Melting Point:254-257°C
Optical Rotation:+30 ~ +36.0° (c=1, H2O)
Long-Term Storage:Store long-term at -20°C

BIOLOGICAL INFO
Application(s):Atpase
Form:Sodium salt
Research Area:Cancer

REVIEW

 Esomeprazole (Nexium) is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells. By inhibiting the functioning of this transporter, the drug prevents formation of gastric acid. The primary uses of esomeprazole are gastroesophageal reflux disease, treatment of duodenal ulcers caused by H. pylori, prevention of gastric ulcers in those on chronic NSAID therapy, and treatment of gastrointestinal ulcers associated with Crohn''s disease. It is used in the treatment of dyspepsia, peptic ulcer disease, gastroesophageal reflux disease and Zollinger-Ellison syndrome. Esomeprazole is the S-enantiomer of omeprazole (brand name Prilosec/Losec).

REFERENCES
[1]Markovic, Nov; Journal of Pharmaceutical and Biomedical Analysis 2006, V42(1), P25-31
[2] Khomenko, T. M.; Russian Journal of Organic Chemistry 2008, V44(1), P124-127
[3] Lindberg, Per Lennart; Von Unge, Sverker; Process for the preparation of optically pure crystalline salts of omeprazole. PCT Int. Appl. (1994), WO 9427988 A1 19941208.
[4] Larsson, Erik Magnus; Stenhede, Urban Jan; Soerensen, Henrik; Von Unge, Per Oskar Sverker; Cotton, Hanna Kristina; Preparation of unsymmetrical heterocyclylsulfoxide enantiomers. PCT Int. Appl. (1996), WO 9602535 A1 19960201.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


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Current as of December 7, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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