161796-78-7 Esomeprazole sodium AKSci V1577
 
 
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  V1577    
Esomeprazole sodium, >98% (HPLC), powder
 
Nexium
IDENTITY
CAS Number:161796-78-7
MDL Number:MFCD07802816
MF:C17H20N3NaO3S
MW:369.41
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:254-257°C
Optical Rotation:+30 ~ +36.0° (c=1, H2O)
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Atpase
Form:Sodium salt
Research Area:Cancer

REVIEW
 Esomeprazole (Nexium) is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells. By inhibiting the functioning of this transporter, the drug prevents formation of gastric acid. The primary uses of esomeprazole are gastroesophageal reflux disease, treatment of duodenal ulcers caused by H. pylori, prevention of gastric ulcers in those on chronic NSAID therapy, and treatment of gastrointestinal ulcers associated with Crohn''s disease. It is used in the treatment of dyspepsia, peptic ulcer disease, gastroesophageal reflux disease and Zollinger-Ellison syndrome. Esomeprazole is the S-enantiomer of omeprazole (brand name Prilosec/Losec).

REFERENCES
[1]Markovic, Nov; Journal of Pharmaceutical and Biomedical Analysis 2006, V42(1), P25-31
[2] Khomenko, T. M.; Russian Journal of Organic Chemistry 2008, V44(1), P124-127
[3] Lindberg, Per Lennart; Von Unge, Sverker; Process for the preparation of optically pure crystalline salts of omeprazole. PCT Int. Appl. (1994), WO 9427988 A1 19941208.
[4] Larsson, Erik Magnus; Stenhede, Urban Jan; Soerensen, Henrik; Von Unge, Per Oskar Sverker; Cotton, Hanna Kristina; Preparation of unsymmetrical heterocyclylsulfoxide enantiomers. PCT Int. Appl. (1996), WO 9602535 A1 19960201.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

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