[3486-67-7] Palmatine AKSci V1557
 
 
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  V1557    
Palmatine
, 98% (HPLC)
 
Berbericinine
Burasaine
O,O-Dimethyldemethyleneberberine




IDENTITY
CAS Number:[3486-67-7]
MDL Number:MFCD00221758
MF:C21H22NO4
MW:352.40
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:NMR, LCMS, HPLC
Physical Form:Yellow powder
Melting Point:215-219°C
Long-Term Storage:Store at room temperature

REVIEW

 Palmatine is a protoberberine isoquinoline alkaloid found in several plants including Phellodendron amurense, Rhizoma coptidis/Coptis Chinensis and Corydalis yanhusuo. Palmatine is an example of an active component of Chinese traditional medicine. It is also the major component of the protoberberine extract from Enantia chlorantha. Palmatine has been studied for its potential use in the treatment of jaundice, dysentery, hypertension, inflammation, and liver-related diseases. The compound also has weak in vitro activity against flavivirus. Palmatine also suppressed West Nile virus without detectable and could also suppress dengue virus and yellow fever virus. Palmatine has also been shown to bind to double stranded DNA and RNA and also been used as penetrating cation conjugates for drugs against various pathologies and aging as mitochondria-targeted antioxidants and selective mild uncouplers.

REFERENCES
[1]Yao Xue Xue Bao. Determination of berberine and palmatine in cortex phellodendron and Chinese patent medicines by HPLC. 1989;24(4):275-9.
[2] Wang YM, Zhao LB, Lin SL, Dong SS, An DK. Virtanen P., Njimi T., Ekotto Mengata D. Clinical trials of hepatitis cure with protoberberine alkaloids of Enantia Chlorantha (abstract) Eur.J.Clin.Pharmacol.36: A123, 1989b.
[3] Bhadra K, Kumar GS. Therapeutic potential of nucleic acid-binding isoquinoline alkaloids: binding aspects and implications for drug design. Med Res Rev. 2011 Nov;31(6):821-62.
[4] Bhadra K, Kumar GS. Interaction of berberine, palmatine, coralyne, and sanguinarine to quadruplex DNA: a comparative spectroscopic and calorimetric study. Biochim Biophys Acta. 2011 Apr;1810(4):485-96.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of March 30, 2017


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CATEGORIES

 APIs and Bioactives > Alkaloids


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