25602-68-0 Nortropinone hydrochloride AKSci V0898
 
 
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  V0898    
Nortropinone hydrochloride, 98% (HPLC)
 
8-Azabicyclo[3.2.1]octan-3-one Hydrochloride
3-Nortropanone Hydrochloride
IDENTITY
CAS Number:25602-68-0
MDL Number:MFCD03613582
MF:C7H11NO.HCl
MW:161.63
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:193-213°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Soluble in Chloroform, Dichloromethane and Methanol.
Application(s):inhibitor of 11beta- hydroxysteroid dehydrogenase type 1 enzyme (11beta-HSD1)

REVIEW
 A tropane-like bicyclic piperidone building block used in drug discovery as a key building block or linker component. Used in exploring a wide range of targets and therapeutics.

REFERENCES
[1]Madge, David; Chan, Fiona; John, Derek Edward; Edwards, Simon D.; Blunt, Richard; Hartzoulakis, Basil; Brown, Lindsay Thienopyrimidines, furopyrimidines, thienopyridines and furopyridines useful as potassium channel inhibitors and their preparation. PCT Int. Appl. (2013), WO 2013072694 A1 20130523.
[2] Schmees, Norbert; Kuhnke, Joachim; Haendler, Bernard; Lienau, Philip; Fernandez-Montalvan, Amaury Ernesto; Lejeune, Pascale; Siegel, Stephan; Scott, William Preparation of 6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines as anticancer agents. PCT Int. Appl. (2013), WO 2013030150 A1 20130307.
[3] Abel, Ulrich; Kubas, Holger; Meyer, Udo; Zemribo, Ronalds Preparation of alkyne substituted azabicyclo[3.2.1]octanes as metabotropic glutamate receptor modulators. PCT Int. Appl. (2012), WO 2012152854 A1 20121115.
[4] Guzzo, Peter R.; Henderson, Alan J.; Isherwood, Matthew; Lee, Chong Yew; Ghosh, Animesh; Zhao, He Preparation of benzofuro[3,2-c]pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators U.S. Pat. Appl. Publ. (2012), US 20120184531 A1 20120719.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P271; P280; P302+P352; P332+P313; P362; P337+P313; P305+P351+P338; P403+P233; P405; P503; P501

Current as of April 26, 2024


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⚠️
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CATEGORIES
 APIs and Bioactives > Alkaloids


PubChem
  @PubMed