201530-41-8 Deferasirox AKSci V0697
 
 
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  V0697    
Deferasirox, 98% (HPLC), powder
 
Deferasiroxum
Exjade
IDENTITY
CAS Number:201530-41-8
MDL Number:MFCD09751362
MF:C21H15N3O4
MW:373.36
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:261-269°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 75mg/mL; H2O: <1mg/mL; EtOH: 2mg/mL
Application(s):Iron Chelating Agent
Form:Free Base

REVIEW
 Arationally-designed oral iron chelator. Its main use is to reduce chronic iron overload in patients who are receiving long-term blood transfusions for conditions such as beta-thalassemia and other chronic anemias.

REFERENCES
[1]List AF, Baer MR, Steensma DP, Raza A, Esposito J, Martinez-Lopez N, Paley C, Feigert J, Besa E (2012). Deferasirox reduces serum ferritin and labile plasma iron in RBC transfusion-dependent patients with myelodysplastic syndrome. J Clin Oncol. 30(17):2134-9. PMID 22547607.
[2] Pullarkat V, Sehgal A, Li L, Meng Z, Lin A, Forman S, Bhatia R (2012). Deferasirox exposure induces reactive oxygen species and reduces growth and viability of myelodysplastic hematopoietic progenitors. Leuk Res. 36(8):966-73. PMID 22502920.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 20, 2024


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⚠️
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