REVIEW Hexadecylpyridinium chloride is a heavily and widely used quaternary (cationic) nitrogen based antiseptic, disinfect or germicide. Hexadecylpyridinium chloride in mouth wash represents an effective agent for halitosis reduction by inhibiting the growth and suppressing the expression of specific genes related to volatile sulfur compounds production in anaerobic periodontal pathogens, and other aspects of oral hygine.
Lottermoser, A.; Steudel, R. The effect of surface-active anions and cations on silver-halogen sols and photographic emulsions. II. Measurement of the absorption of surface-active alkyl pyridine cations by silver iodide Kolloid-Zeitschrift (1938), 83, 37-51.
Sano, Kimihiko; Urano, Yoji; Kimura, Takuhiro; Sano, Atsnori A continuous process for the synthesis of quaternary ammonium salts (e.g. alkyl(pyridinium/imidazolium) halides) Eur. Pat. Appl. (2001), EP 1125927 A1 20010822.
Liu J, Ling JQ, Wu CD. Cetylpyridinium chloride suppresses gene expression associated with halitosis. Arch Oral Biol. 2013 Nov;58(11):1686-91.
Costa X, Laguna E, Herrera D, Serrano J, Alonso B, Sanz M. Efficacy of a new mouth rinse formulation based on 0.07% cetylpyridinium chloride in the control of plaque and gingivitis: a 6-month randomized clinical trial. J Clin Periodontol. 2013 Aug 14.