111011-76-8 Efonidipine hydrochloride monoethanolate AKSci U165
 
 
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  U165    
Efonidipine hydrochloride monoethanolate
, 98% (HPLC)
 



IDENTITY
CAS Number:111011-76-8
MDL Number:MFCD00875717
MF:C34H38N3O7P.HCl.C2H5OH
MW:714.18
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Spectra:NMR, LCMS, HPLC
Physical Form:Yellow powder
Melting Point:150-154°C
Long-Term Storage:Store long-term at 2-8°C

BIOLOGICAL INFO
Solubility:Soluble to 100 mM in DMSO

REVIEW

 Selective blocker of L-type and T-type Ca2+ channels. Displays minimal inhibition of N- and P/Q-type channels and no inhibition of R-type channels. R(-) and S(+)-enantiomers display different channel selectivity; S(+)-Efonidipine blocks L-type and T-type channels whereas R(-)-Efonidipine displays selectivity for T-type channels. Exhibits antihypertensive activity.

REFERENCES
[1]GUO Yi-meng, WU Li-ying, CHINESE JOURNAL OF MEDICINAL CHEMISTRY 2008 18 (1): 35-37

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of July 7, 2020


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CATEGORIES

 APIs and Bioactives > Calcium Channel Blockers


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