870061-27-1 A-839977 AKSci SYN5005
 
 
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  SYN5005    
A-839977
, >95%
 



IDENTITY
CAS Number:870061-27-1
MDL Number:MFCD19690959
MF:C19H14Cl2N6O
MW:413.26
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>95%
Long-Term Storage:Store at room temperature
HAZARDOUS MATERIALS INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:100 mM in DMSO

REVIEW

 A-839977 is a potent, CNS penetrating P2X7 antagonist whixh blocks BzATP-evoked calcium influx at P2X7 receptors. (IC50 values are 20nM - human, 42nM -rat and 150nM - mouse). A-839977 displays antinociceptive effects in rat and mice models of inflammatory pain.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of September 24, 2020


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