1403254-99-8 EPZ-6438 AKSci SYN3045
 
 
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  SYN3045    
EPZ-6438
, >95%
 
EPZ6438




IDENTITY
CAS Number:1403254-99-8
MDL Number:MFCD24849415
MF:C34H44N4O4
MW:572.75
SPECIFICATIONS & PROPERTIES
Purity:>95%
Physical Form:Solid
Density:1.2
Refractive Index:1.58
Long-Term Storage:Store at room temperature

REVIEW

 Inactivation of the switch/sucrose nonfermentable complex component SMARCB1 is extremely prevalent in pediatric malignant rhabdoid tumors (MRTs) or atypical teratoid rhabdoid tumors. EPZ-6438 induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells. Treatment of xenograft-bearing mice with EPZ-6438 leads to dose-dependent regression of MRTs with correlative diminution of intratumoral trimethylation levels of lysine 27 on histone H3, and prevention of tumor regrowth after dosing cessation.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of November 13, 2019


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.



PubChem