1038395-65-1 KW-2449.HCl AKSci SYN1205
 
 
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  SYN1205    
KW-2449.HCl
, 98%
 
KW2449, N-Benzyl-2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]pyridin-2-yl]acetamide hydrochloride




IDENTITY
CAS Number:1038395-65-1
MDL Number:MFCD28010197
MF:C20H20N4O.HCl
MW:368.86
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:Solid
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:DMSO 67mg/mL, Ethanol < 67mg/mL
Application(s):Aurora A - Abl - FGFR - BCR - fms

REVIEW

 Flt3 is the primary target of KW-2449 (IC50 of 6.6 nM). It is significantly less potent against FGFR1, Bcr-Abl and Aurora A, with only minor effects against PDGFRβ, IGF-1R, EGFR. KW-2449 is currently undergoing Phase I trials.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of April 8, 2020


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.