1357158-81-6 AZD-26 AKSci SYN1160
 
 
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  SYN1160    
AZD-26
, >95%
 
AZD26




IDENTITY
CAS Number:1357158-81-6
MDL Number:MFCD25977103
MF:C22H21N3O
MW:343.42
SPECIFICATIONS & PROPERTIES
Purity:>95%
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:DMSO 112mg/mL, Ethanol 4mg/mL
Application(s):AKT

REVIEW

 AZD is an inhibitor of AKT. AZD-26 inhibits the phosphorylation of Thr308 on AKT in BT474 cells with an IC50 of 422 nM. It also inhibits the phosphorylation of Ser473 on AKT in MDAMB468 cells with an IC50 of 322 nM. In numerous published cell assays using rodent and human model systems AZD-26 inhibited AKT mediated phosphorylation at ranges form 0.01 μM t0 10μM after 24 hour exposure. LIkewise AZD-25 used at 100-200mg/kg also inhibited AKT phosphorylation and subsequent activation.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of July 19, 2019


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