REVIEW AZD is an inhibitor of AKT. AZD-26 inhibits the phosphorylation of Thr308 on AKT in BT474 cells with an IC50 of 422 nM. It also inhibits the phosphorylation of Ser473 on AKT in MDAMB468 cells with an IC50 of 322 nM. In numerous published cell assays using rodent and human model systems AZD-26 inhibited AKT mediated phosphorylation at ranges form 0.01 μM t0 10μM after 24 hour exposure. LIkewise AZD-25 used at 100-200mg/kg also inhibited AKT phosphorylation and subsequent activation.
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