552325-73-2 (free base) A-674563 HCl AKSci SYN1110
 
 
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  SYN1110    
A-674563 HCl
, >95%
 
A674563




IDENTITY
CAS Number:552325-73-2 (free base)
MDL Number:MFCD18711680
MF:C22H22N4O.HCl
MW:394.9
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>95%
Physical Form (at 20°C):Solid
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO 72 mg/mL, Ethanol <12 mg/mL
Application(s):AKT - PKA - CDK7 - CDK5 - CDK4 - CDK2

REVIEW

 A-674563 is a potent, orally available Akt1 inhibitor with an IC50 of 11 nM. It also displays activity against PKA and CDK2 with IC50 values of 16 and 46 nM respectively.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of June 22, 2024


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