827318-97-8 Danusertib AKSci SYN1095
 
 
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  SYN1095    
Danusertib
, >95%
 
PHA-739358




IDENTITY
CAS Number:827318-97-8
MDL Number:MFCD12024692
MF:C26H30N6O3
MW:474.55
SPECIFICATIONS & PROPERTIES
Purity:>95%
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:DMSO 95 mg/mL, Ethanol 34mg/mL
Application(s):Abl - Aurora A - BCR - FGFR

REVIEW

 Aurora kinases are key regulators of protein phosphorylation during mitosis, and these serine/threonine kinases interact with other cellular proteins to help control chromosome assembly and segregation during mitosis. Aurora kinases are often highly expressed in malignancies and solid tumors. Danusertib (PHA-739358) is a small molecule pan- Aurora kinase inhibitor that also has activity against other cancer-relevant kinases such as Bcr-Abl tyrosine kinase. Other off target effects of danusertib include inhibition of receptor tyrosine kinases such as FGFR-1, and TrkA. Danusertib demonstrates nanomolar IC50 values for the Aurora kinases all under 100 nM and it also demonstrates potent anti-proliferation effects in cell proliferation assays with IC50 values ranging from 20 nM for A2780 cells to <200 nM.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 16, 2019


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.