REVIEW BMS387032 is a novel cyclin-dependent kinase inhibitor, which exhibits potent and selective inhibitory activity against Cdk2, Cdk7, and Cdk9. It inhibits CDK2 with an IC50 of 48 nM and up to 20-fold selective over CDK1/CDK4. It also inhibits CDK7/9 with IC50 values of 62 nM and 4 nM. It has little effect on CDK6.
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