443797-96-4 JNJ-7706621 AKSci SYN1048
 
 
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  SYN1048    
JNJ-7706621
, 98%
 
4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-ylamino)benzenesulfonamide




IDENTITY
CAS Number:443797-96-4
MDL Number:MFCD11100270
MF:C15H12F2N6O3S
MW:394.36
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%
Physical Form (at 20°C):Solid
Melting Point:149-155℃°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO 79mg/mL, Ethanol 1mg/mL
Application(s):Aurora A - CDK7 - CDK5 - CDK4 - CDK2

REVIEW

 JNJ-7706621 is a dual inhibitor of cyclin-dependent kinases (CDK) and Aurora kinases. It demonstrates highest potency on CDK1/2 with IC50 values of 9 nM and 4 nM respectively. It shows more than 6-fold selectivity for CDK1/2 over CDK3/4/6.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of April 15, 2024


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⚠️
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