896466-04-9 AT9283 AKSci SYN1011
 
 
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  SYN1011    
AT9283
, >95%
 



IDENTITY
CAS Number:896466-04-9
MDL Number:MFCD12031513
MF:C19H23N7O2
MW:381.43
SPECIFICATIONS & PROPERTIES
Purity:>95%
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:DMSO 76mg/mL, Ethanol 38mg/mL
Application(s):Aurora A

REVIEW

 Aurora kinases play a key role in the regulation of mitosis and in recent years have become attractive targets for the treatment of cancer. AT9283 is a powerful inhibitor of Aurora A and B kinases as well as several other important kinases including JAK2 and Abl (T315I). AT9283 has also been shown effective in mouse xenograft models and has been studied as a possible clinical candidate. Effective IC50 doses for Aurora kinases are in the low 2-3 nM range, and inhibition of a number of other kinases including JAK2 has been reported at 1-10nM.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of December 12, 2018


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