25683-71-0 Terizidone AKSci S112
 
 
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  S112    AKSci Reference Standard
Terizidone
, 98% (HPLC), powder
 
Terizidon
Terizidona
Terizidonum
more..




IDENTITY
CAS Number:25683-71-0
MDL Number:MFCD00866818
MF:C14H14N4O4
MW:302.29
EINECS:247-186-1
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:203-205°C
Optical Rotation:+160° - +167° (c=1, 0.1N NaOH)
Density:1.52
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW

 Terizidone is a drug used in the treatment of tuberculosis. Terizidone is part of a group of drugs used in the treatment of drug resistant TB called oral bacteriostatic second-line agents. It is used as part of treatment regimens, generally involving 5 medicines, to treat MDR and XDR TB. Terizidone is obtained by combining two molecules of cycloserine.

REFERENCES
[1]Felder, Ernst; US 3117122 1964
[2] Bonati F, Bertoni L, Rosati G, Zanichelli V.Biologic characteristics and antibacterial activity of Terizidone]. Endokrinologie. 1965 Mar;47(5):381-95.
[3] Mancini, Pieralfredo; Matzeu, M.; Lucchesi, M Antimycobacterial activity of cycloserine and terizidone in vitro Annali dell'Istituto Carlo Forlanini (1968), 28(2), 105-15.
[4] Zitkova, L.; Janku, I.; Tousek, J.; Papezova, E.; Stastna, J. Pharmacokinetics of antituberculosis drugs after oral single and simultaneous administration in triple combination Czechoslovak Medicine (1983), 6(4), 202-17.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of September 21, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Antibacterials


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