REVIEW Mecamylamine is a ganglionic blocker which prevents stimulation of postsynaptic receptors by acetylcholine released from presynaptic nerve endings. The hypotensive effect of Mecamylamine is attributed to reduction in sympathetic tone, vasodilation, and reduced cardiac output, and is primarily postural.
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Lippiello PM, Beaver JS, Gatto GJ, et al (2008). TC-5214 (S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity. CNS Neurosci Ther 14 (4): 266-77. doi:10.1111/j.1755-5949.2008.00054.x. PMID 19040552.
Shytle RD, Penny E, Silver AA, Goldman J, Sanberg PR (July 2002). Mecamylamine (Inversine): an old antihypertensive with new research directions. J Hum Hypertens 16 (7): 453-7. doi:10.1038/sj.jhh.1001416. PMID 12080428.
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